Swainsonine producing performance of Alternaria oxytropis was improved by heavy-ion mutagenesis technology
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چکیده
منابع مشابه
The Genome of Undifilum oxytropis Provides Insights into Swainsonine Biosynthesis and Locoism
Undifilum oxytropis is a fungal endophyte of locoweeds. It produces swainsonine, which is the principal toxic ingredient of locoweeds. However, the genes, pathways and mechanisms of swainsonine biosynthesis are not known. In this study, the genome of U. oxytropis was firstly sequenced and assembled into a 70.05 megabases (Mb) draft genome, which encoded 11,057 protein-coding genes, and 54% of t...
متن کاملTissue swainsonine clearance in sheep chronically poisoned with locoweed (Oxytropis sericea).
Locoweed poisoning is seen throughout the world and annually costs the livestock industry millions of dollars. Swainsonine inhibits lysosomal alpha-mannosidase and Golgi mannosidase II. Poisoned animals are lethargic, anorexic, emaciated, and have neurologic signs that range from subtle apprehension to seizures. Swainsonine is water-soluble, rapidly absorbed, and likely to be widely distributed...
متن کاملPotential role for saccharopine reductase in swainsonine metabolism in endophytic fungus, Undifilum oxytropis.
Locoweed plants in the southwestern United States often harbour a slow-growing endophytic fungus, Undifilum oxytropis (Phylum: Ascomycota; Order: Pleosporales), which produces a toxic alkaloid, swainsonine. Consumption of U. oxytropis by grazing animals induces a neurological disorder called locoism for which the toxic alkaloid swainsonine has been reported to be the causal agent. Little is kno...
متن کاملAppearance and disappearance of swainsonine in serum and milk of lactating ruminants with nursing young following a single dose exposure to swainsonine (locoweed; Oxytropis sericea).
A series of experiments were conducted to investigate the elimination of swainsonine in the milk of lactating ruminants following a single dose oral exposure to swainsonine (locoweed; Oxytropis sericea) and to assess subsequent subclinical effects on the mothers and their nursing young. In a preliminary experiment, lactating ewes were gavaged with locoweed providing 0.8 mg swainsonine/kg BW (n ...
متن کاملImproved Performance of the Gsi Heavy Ion Accelerator Complex with Cooled Synchrotron Beams
Electron cooling at the injection energy of the heavy ion synchrotron SIS results in beam pulses of higher intensity and exceptional quality. The beam parameters after cooling have been measured and verify a reduction of the phase space volume by more than three orders of magnitude. Beam transfer of the cooled ion beam is much easier because of the reduced emittance. The time required to fill t...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 2021
ISSN: 1574-6968
DOI: 10.1093/femsle/fnab047